Canadian researchers will study whether the plasma of recovered patients can be used to treat COVID-19, in an April 9, 2020 story. (Photo by THE CANADIAN PRESS)

Researchers to study whether plasma of recovered patients can treat COVID-19

Plasma is the liquid portion of the blood that contains the antibodies that protect against illness

Researchers from across Canada will collaborate on a vast clinical trial to study whether the plasma of recovered patients can be used to treat COVID-19.

The study, the largest to date ever done on the subject, will include about 50 Canadian institutions, including 15 in Quebec.

“It’s a therapy to treat the illness,” said one of the lead researchers, Dr. Philippe Begin of Montreal’s CHU Ste-Justine hospital.

“We’re talking about passive immunizations, while with a vaccine we’re talking about active immunization.”

Passive immunization consists of transfusing plasma from patients who have recovered from COVID-19 — called convalescent plasma — to patients in the early stages of the illness in order to provide protective antibodies and hopefully limit the severity of symptoms.

Plasma is the liquid portion of the blood that contains the antibodies that protect against illness.

Begin cited the proverb, “Give a man a fish and feed him for a day; teach a man to fish and feed him for a lifetime.” Teaching someone to fish, he said, would be the equivalent of a vaccine that prompts the body to make its own antibodies.

But with no vaccine available, convalescent plasma is the best alternative.

ALSO READ: ‘Tremendous’ response from blood donors has supply keeping pace with demand

“But now we don’t have time, because we don’t yet know how to fish, so we can’t really teach it,” he said. “So the idea is that we just give the antibodies created by someone else.”

The approach was used before the development of vaccines to combat epidemics, and it’s not the first time the idea of using convalescent plasma has been raised in the fight against COVID-19. But thus far, the evidence in favour remains largely anecdotal and of poor scientific quality.

The study will include researchers from the Universite de Montreal, the Jewish General Hospital in Montreal, Hema-Quebec, McMaster University, and Sunnybrook and SickKids hospitals in Toronto, among others.

Begin admitted researchers are running “a little blind” when it comes to the use of plasma.

“We don’t have a ton of studies that tell us, it takes this kind of antibody, or this amount of plasma,” he said.

The best way to get answers is to assemble as much data as possible, as quickly as possible, he said.

“We want to go fast, and the best way to go fast is have several of us following the same protocol to put all the data together,” he said.

“We have colleagues in other countries who are interested and with whom we share our protocols.”

Plasma will be collected about a month after a patient recovers, when antibody levels are at their highest. COVID-19 was first reported in Quebec in late February, and the number of potential donors in the province remains low, although it’s growing.

Therefore, the researchers have decided the convalescent plasma will be reserved for those who are suffering from the illness, although it’s not out of the question that it could be offered later to at-risk groups, such as health-care workers, as a preventive measure.

The study is expected to last about three months and involve more than 1,000 patients.

Jean-Benoit Legault, The Canadian Press

Like us on Facebook and follow us on Twitter.

Coronavirus

Get local stories you won't find anywhere else right to your inbox.
Sign up here

Just Posted

Allison Sutton awarded the 2020 Ina Kaebe Child Care Provider Memorial Award

Sutton has been a child care provider in Quesnel ofr the past 10 years

Letters to Dunrovin

Letters To Seniors project is connecting communities to care home residents during COVID-19

Quesnel School District opens playgrounds

School playgrounds have opened as of Friday, June 5

Quesnel Farmers’ Market welcomes back non-food vendors

Decision comes as the Province moves forward with phase two of the B.C. Restart Plan

Barkerville set to re-open in phases

Accomodations, shops, restaraunts to open June 18, exhibits and public programming July 3

Trudeau offers $14B to provinces for anti-COVID-19 efforts through rest of year

Making a difference in municipalities is a pricey proposition

‘I’m pissed, I’m outraged’: Federal minister calls out police violence against Indigenous people

Indigenous Minister Marc Miller spoke on recent incidents, including fatal shooting of a B.C. woman

Indigenous families say their loved ones’ deaths in custody are part of pattern

Nora Martin joins other Indigenous families in calling for a significant shift in policing

‘Alarmed’: Health critic calls for more data on COVID-19 in trucking industry

Saskatchewan, Ontario and Quebec said that level of detail is not being collected

UPDATED: Pair accused of ‘horrific’ assault at Vancouver’s Oppenheimer Park arrested

Police say Jason Tapp, 30, and Nicole Edwards, 33, did not show up to meet their bail supervisor this week

Kelowna Mountie who punched suspect identified, condemned by sister

‘How did he get away with this? How is this justifiable?’

PHOTOS: Anti-racism protesters gather in communities across B.C.

More protests are expected through the weekend

No charges to be laid against 22 northern B.C. pipeline protesters

Twenty-two people were arrested in February, but Crown has decided not to pursue charges

Most Read